The aim of this work was formulation and characterization of venlafaxine fast dissolving films containing venlafaxine is a bicyclic antidepressant and is usually categorized as a serotonin-norepinephrine reuptake inhibitor (SNRI), but it has been referred to as a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI). Films were formulated using film forming polymer like Hydroxypropylmethylcellulose (HPMC E5) (F1 – F4) and mixture of HPMC E5 and Polyoxyethylenesorbitan-monooleate (TWEEN 80) (F5 – F8) were prepared by solvent casting technique with the help of Polyethylene glycol (PEG 400) as a plasticizer and glycerine as a sweetening agent. Fourier transform infrared spectroscopic analysis was performed to study the interaction between the drug and polymer respectively. The films were evaluated for weight variation, surface pH , folding endurance, drug content, dissolving time, disintegration time, in-vitro dissolution studies. Based on the evaluation parameters F1 containing Drug:Polymer (1:1) ratio showed optimum performance and marked increase in releasing of drug 87.99%, though F5 formulation has maximum drug release as it has less tensile strength. It can be concluded in the study that mouth dissolving film can be potential novel drug dosage form for poorly water soluble drugs.
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